A chief concern affecting quality of life among young adult (YA) cancer survivors is fertility. Although discussions regarding the possibility of infertility and methods to decrease the risk are crucial at the time of diagnosis, many YAs don’t remember having adequate discussions regarding these topics before the initiation of their treatment. Embryo cryopreservation in women and sperm cryopreservation in men before cancer therapy remains to be the most effective ways in which fertility is preserved in the YA population. Although female and male gonadal tissue cryopreservation and transplantation remain experimental, such options are explored and continuously researched through programs such as the Oncofertility Consortium at Northwestern University.
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Nonmalignant Diseases and Treatments Associated with Primary Ovarian Failure: An Expanded Role for Fertility Preservation.
J Womens Health (Larchmt). 2011 Aug 9;
Authors: Hirshfeld-Cytron J, Gracia C, Woodruff TK
Abstract Cancer treatments can be detrimental to fertility; recent literature has focused on the efforts of fertility preservation for this patient population. It should be recognized, however, that several nonmalignant medical conditions and therapeutic interventions could be similarly...
[Female fertility preservation: Feasibility of emergency IVF for embryo freezing.]
Gynecol Obstet Fertil. 2011 Aug 3;
Authors: Courbiere B, Saias-Magnan J, Metzler-Guillemain C, Perrin J, Noizet A, Gamerre M
With the improvement of the anticancerous treatments, the preservation of the feminine fertility before gonadotoxic treatment tends at present to stand out as a legal obligation, with a duty of information to patients. When emergency IVF can be performed, the cryopreservation of embryos is the...
Estrogen receptor α single nucleotide polymorphism modifies the risk of azoospermia in childhood cancer survivors.
Pharmacogenet Genomics. 2011 May;21(5):263-9
Authors: Romerius P, Giwercman A, Moëll C, Relander T, Cavallin-Ståhl E, Wiebe T, Halldén C, Giwercman YL
Cancer treatment in childhood leads to permanent azoospermia in a significant number of boys and those who are diagnosed with cancer before puberty do not have the option of pretreatment cryopreservation of spermatozoa. However, there is...
Fertility Outcome After Radical Vaginal Trachelectomy: A Prospective Study of 212 Patients.
Int J Gynecol Cancer. 2011 Jul 7;
Authors: Speiser D, Mangler M, Köhler C, Hasenbein K, Hertel H, Chiantera V, Gottschalk E, Lanowska M
OBJECTIVE:: For treatment in patients with early-stage cervical cancer, radical vaginal trachelectomy (RVT) as a fertility-preserving surgery can be put on a par with radical hysterectomy as to oncologic safety. Our aim was to investigate the fertility concerns and outcome....
Unknown risk of the reintroduction of malignant cells in a Danish cohort of women autotransplanted with ovarian tissue.
Fertil Steril. 2011 Jun;95(7):e52; author reply e53
Authors: Bastings L, Westphal JR, Beerendonk CC, Braat DD, Peek R
PMID: 21507398 [PubMed - indexed for MEDLINE]
Early adenocarcinoma of the cervix: Is radical vaginal trachelectomy safe?
Gynecol Oncol. 2011 Jul 18;
Authors: Helpman L, Grisaru D, Covens A
OBJECTIVE: Radical vaginal trachelectomy (RVT) is a revolutionary option for fertility preservation in young women with early cervical tumors. Several series have demonstrated outcomes comparable to radical hysterectomy (RH), but none has addressed the influence of histology. We evaluated the safety of RVT in adenocarcinomas. METHODS: Data on surgically...
Oncologists' use of patient educational materials about cancer and fertility preservation.
Psychooncology. 2011 Jul 14;
Authors: Quinn GP, Vadaparampil ST, Malo T, Reinecke J, Bower B, Albrecht T, Clayman ML
BACKGROUND: This study sought to determine the prevalence of distribution of fertility preservation (FP) materials, source of the materials, and providers' perceived relevance of the materials among a sample of US oncologists. METHODS: A 53-item survey was administered via mail and the Web to a...
Management of Early Invasive Breast Cancer in Very Young Women (<35 years).
Clin Breast Cancer. 2011 Jul 11;
Authors: Hartmann S, Reimer T, Gerber B
BACKGROUND: To give an overview about current treatment recommendations and special problems concerning the management of women <35 years with early breast cancer. METHODS: We performed a selective systematic literature review. We discussed with reference to key studies and meta-analyses, current standards of care, and controversies regarding...
Discussing fertility preservation options with patients with cancer.
JAMA. 2011 Jul 13;306(2):202-3
Authors: Snyder KA, Pearse W
PMID: 21750299 [PubMed - indexed for MEDLINE]
Fertility determinants after conservative surgery for mucinous borderline tumours of the ovary (excluding peritoneal pseudomyxoma).
Hum Reprod. 2011 Apr;26(4):808-14
Authors: Koskas M, Uzan C, Gouy S, Pautier P, Lhommé C, Haie-Meder C, Duvillard P, Morice P
BACKGROUND The aim of this study was to define determinants of fertility in patients treated conservatively for mucinous borderline ovarian tumours (MBOTs), and to compare outcomes after salpingo-oophorectomy or cystectomy. METHODS This was a...
Surgery of ovarian tumors in children.
Horm Res Paediatr. 2011;75(3):220-4
Authors: Sarnacki S, Brisse H
Surgery of ovarian tumors in children requires a good knowledge of these lesions. Complete resection is mandatory for malignant lesions, and in the case of benign tumors preservation of healthy ovarian tissue is crucial. Diagnosis is based on clinical features (age and hormonal status), imaging and tumor marker levels. Laparoscopy is of great help in making a diagnosis and staging when the...
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